Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 5/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 10/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790365 | 1.00 | HTR1B (0.61) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888353 | 0.92 | HTR1B (0.59) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888877 | 0.91 | HTR1B (0.58) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888071 | 0.91 | HTR1B (0.58) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8887494 | 0.91 | HTR1B (0.60) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8887071 | 0.91 | HTR1B (0.60) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8888251 | 0.90 | HTR1B (0.56) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8887098 | 0.90 | HTR1B (0.64) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8903089 | 0.90 | HTR1B (0.56) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL9030541 | 0.90 | HTR1B (0.59) | HTR1BHTR1ACHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0592438-B1 | INDOLE DERIVATIVES | PFIZER (US) | 1997-08-27 | — | — | EP | disclosed |
| US-5607951-A | SEROTONIN AGONIST FOR NERVOUS SYSTEM DISORDERS, ANALGESICS AND PSYCHOTHERAPEUTICS | PFIZER INC (US) | 1997-03-04 | — | — | US | disclosed |
| US-5578612-A | Indole derivatives | PFIZER INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5559246-A | PROCESS OF DEHYDROHALOGENATION FOR CYCLIZATION TO PRODUCE PSYCHOTHERAPEUTIC AGENTS AND ANTISEROTONIN ANTAGONIST | PFIZER INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5545644-A | SEROTONIN AGONISTS; HYPOTENSIVE AND ANXIOLYTIC AGENTS; ANALGESICS; ANTIDEPRESSANTS; EATING DISORDERS; DRUG ABUSE; HEADACHES; VASCULAR DISORDERS | PFIZER INC. (US) | 1996-08-13 | — | — | US | disclosed |