SCHEMBL8790612

SCHEMBL8790612

CC1=C(C(=O)OCCN)C(c2cccc(C#N)c2)C(C(=O)OCCN)=C(C)N1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 10/20 0.70
CACNA1D Q01668 10/20 0.70
CACNA1S Q13698 10/20 0.70
CACNA1C Q13936 10/20 0.70
ADORA3 P0DMS8 2/20 0.51
CACNA1B Q00975 1/20 0.49
MEN1 O00255 3/20 0.48
CYP1A2 P05177 3/20 0.48
CYP3A4 P08684 3/20 0.48
CYP2C9 P11712 3/20 0.48
CYP2C19 P33261 3/20 0.48
KMT2A Q03164 3/20 0.48
LMNA P02545 3/20 0.48
MAPT P10636 2/20 0.48
CYP2D6 P10635 1/20 0.48
TSHR P16473 1/20 0.48
NFKB1 P19838 1/20 0.48
THPO P40225 1/20 0.48
NOTCH1 P46531 1/20 0.48
HIF1A Q16665 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7479321 0.99 CACNA1F (0.69) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7162565 0.90 CACNA1F (0.72) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL6946910 0.88 CACNA1C (0.67) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7156469 0.88 CACNA1F (0.76) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL8914777 0.88 CACNA1C (0.64) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7273470 0.86 CACNA1F (0.67) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7156628 0.86 CACNA1F (0.80) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10745598 0.86 CACNA1C (0.70) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL11109811 0.86 CACNA1F (0.67) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10891300 0.85 CACNA1F (0.66) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779277-A1 1,4-DIHYDROPYRIDINE DERIVATIVE MERCIAN CORPORATION (JP) 1997-06-18 EP disclosed