SCHEMBL8792008

SCHEMBL8792008

Brc1cccc(-c2[nH]c(-c3ccccc3Br)nc2-c2ccncc2)c1

nearest known ligand 0.68

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 17/20 0.68
MAPK13 O15264 15/20 0.68
MAPK12 P53778 15/20 0.68
MAPK11 Q15759 15/20 0.68
GCGR P47871 6/20 0.68
TEK Q02763 1/20 0.59
RAF1 P04049 9/20 0.55
MAPK9 P45984 1/20 0.55
CSNK1D P48730 2/20 0.52
CSNK1E P49674 2/20 0.52
ALOX5 P09917 2/20 0.49
BRAF P15056 2/20 0.49
BRDT Q58F21 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6470581 0.84 MAPK13 (0.81) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL6003680 0.81 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL5197475 0.81 MAPK14 (0.77) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL8791626 0.81 MAPK14 (0.77) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL22408459 0.81 MAPK13 (0.68) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL30097907 0.81 MAPK13 (0.68) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL6470570 0.80 MAPK14 (0.74) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL8791164 0.78 MAPK14 (0.61) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL2649482 0.78 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL6469901 0.78 MAPK14 (0.78) MAPK14MAPK13MAPK12MAPK11GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0797575-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1997-10-01 EP claimed
WO-1996018626-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1996-06-20 WO claimed
EP-0797575-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1997-10-01 EP disclosed
WO-1996018626-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1996-06-20 WO disclosed