Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RARG | P13631 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8792757 | 0.85 | AKR1B1 (0.49) | AKR1B1ALDH1A1KMT2ACYP26A1CYP26B1 | |
| SCHEMBL8793940 | 0.85 | AKR1B1 (0.49) | AKR1B1ALDH1A1KMT2ACYP26A1CYP26B1 | |
| SCHEMBL8794472 | 0.85 | AKR1B1 (0.49) | AKR1B1ALDH1A1KMT2ACYP26A1CYP26B1 | |
| SCHEMBL8794218 | 0.85 | AKR1B1 (0.49) | AKR1B1ALDH1A1KMT2ACYP26A1CYP26B1 | |
| SCHEMBL8794386 | 0.85 | AKR1B1 (0.70) | AKR1B1MAPT | |
| SCHEMBL8795191 | 0.85 | AKR1B1 (0.49) | AKR1B1ALDH1A1KMT2ACYP26A1CYP26B1 | |
| SCHEMBL8793923 | 0.82 | AKR1B1 (0.46) | AKR1B1ALDH1A1KMT2ARARARARB | |
| SCHEMBL167946 | 0.81 | AKR1B1 (0.47) | AKR1B1ALDH1A1KMT2ATSHRGAA | |
| SCHEMBL29579029 | 0.81 | AKR1B1 (0.47) | AKR1B1ALDH1A1KMT2ATSHRGAA | |
| SCHEMBL8794542 | 0.81 | AKR1B1 (0.52) | AKR1B1ALDH1A1KMT2AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696050-A | APPLYING TO CROP PLANT, SEED OR SURROUNDING SOIL OR WATER ANTIDOTAL AMOUNT OF PLANT SAFENING AGENT | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0496314-B1 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-10-01 | — | — | EP | disclosed |
| EP-0613618-B1 | Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds | AMERICAN CYANAMID CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5516918-A | PLANT SAFTENING AGENTS USING BENZOPYRAN-4-ACETIC ACIDS OR BENZOTHIOPYRAN-4-ACETIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1996-05-14 | — | — | US | disclosed |
| US-5407897-A | Plant safening agents | AMERICAN CYANAMID COMPANY (US) | 1995-04-18 | — | — | US | disclosed |
| EP-0613618-A1 | Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds | AMERICAN CYANAMID COMPANY (US) | 1994-09-07 | — | — | EP | disclosed |
| EP-0496314-A1 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-29 | — | — | EP | disclosed |