Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | GMNN | O75496 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | THPO | P40225 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8792577 | 0.90 | MAPK14 (0.56) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| SCHEMBL17002178 | 0.88 | MAPK14 (0.63) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| SCHEMBL8793341 | 0.88 | MAPK14 (0.63) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| SCHEMBL17002222 | 0.87 | MAPK14 (0.76) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| SCHEMBL18960509 | 0.83 | MAPK14 (0.83) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| SCHEMBL6447986 | 0.83 | MAPK14 (0.69) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| SCHEMBL6971902 | 0.81 | MAPK14 (0.68) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| SCHEMBL6957125 | 0.79 | MAPK14 (0.58) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| Pd-169316 SCHEMBL9899161 | 0.78 | MAPK14 (1.00) | MAPK14MAPK11ALOX5MAPK13MAPK12 | |
| Pd-169316 SCHEMBL154958 | 0.78 | MAPK14 (1.00) | MAPK14MAPK11ALOX5MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797575-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-01 | — | — | EP | claimed |
| WO-1996018626-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-20 | — | — | WO | claimed |
| EP-0797575-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-01 | — | — | EP | disclosed |
| EP-0669830-A4 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1997-02-26 | — | — | EP | disclosed |
| WO-1996018626-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-20 | — | — | WO | disclosed |
| EP-0669830-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-09-06 | — | — | EP | disclosed |