Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.69 |
| ▸ | SYK | P43405 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | AURKA | O14965 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185480 | 0.86 | EGFR (0.55) | EGFRSYKKDRIGF1R | |
| SCHEMBL12185449 | 0.85 | EGFR (0.54) | EGFRSYKKDRCDK1IGF1R | |
| SCHEMBL5105139 | 0.84 | MAPKAPK2 (0.65) | EGFR | |
| SCHEMBL10049851 | 0.84 | EGFR (0.53) | EGFRSYKKDR | |
| SCHEMBL30138092 | 0.84 | EGFR (0.53) | EGFRSYKKDR | |
| Hydrochloric Acid SCHEMBL12821490 | 0.83 | SYK (0.57) | EGFRSYKJAK2 | |
| SCHEMBL1926495 | 0.82 | PLK1 (0.73) | EGFRSYKKDRAURKAMAPK1 | |
| SCHEMBL31156703 | 0.81 | EGFR (0.56) | EGFRSYKKDRIGF1R | |
| SCHEMBL6260423 | 0.81 | EGFR (0.51) | EGFRSYKKDRNPC1RAB9A | |
| SCHEMBL28942655 | 0.81 | EGFR (0.80) | EGFRKDRAURKAPIM1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433636-A1 | Treatment of Malignant Diseases | Medizinische Universität Wien (AT) | 2012-03-28 | — | — | EP | disclosed |