Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 14/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846913 | 0.84 | MAPK8 (0.84) | MAPK8MAPK9MAPK10 | |
| SCHEMBL846797 | 0.83 | MAPK8 (0.70) | MAPK8MAPK9MAPK10USP2SMN1; SMN2 | |
| SCHEMBL848334 | 0.82 | MAPK8 (0.68) | MAPK8MAPK9MAPK10USP2SMN1; SMN2 | |
| SCHEMBL847016 | 0.76 | MAPK8 (0.83) | MAPK8MAPK9MAPK10 | |
| SCHEMBL847557 | 0.76 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL2616538 | 0.75 | MAPK8 (0.80) | MAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL847556 | 0.75 | MAPK8 (0.98) | MAPK8MAPK9MAPK10 | |
| SCHEMBL847389 | 0.75 | MAPK8 (0.83) | MAPK8MAPK9MAPK10 | |
| SCHEMBL848283 | 0.74 | MAPK8 (0.76) | MAPK8MAPK9MAPK10 | |
| SCHEMBL845606 | 0.74 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-B1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2012-03-28 | — | — | EP | disclosed |