Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797455 | 0.87 | LPAR1 (0.37) | LPAR1KMT2ALMNAHDAC4HDAC7 | |
| Hydrochloric Acid SCHEMBL8797870 | 0.86 | LPAR1 (0.36) | LPAR1KMT2ALMNAHDAC4HDAC7 | |
| SCHEMBL8797399 | 0.85 | LPAR1 (0.36) | LPAR1KMT2ALMNAHDAC4HDAC7 | |
| SCHEMBL8797482 | 0.84 | LPAR1 (0.45) | LPAR1KMT2ALMNAHDAC4HDAC7 | |
| SCHEMBL8797371 | 0.83 | TP53 (0.42) | LPAR1KMT2ALMNAHDAC4HDAC7 | |
| SCHEMBL8797883 | 0.83 | LPAR1 (0.46) | LPAR1KMT2ALMNAHDAC4HDAC7 | |
| SCHEMBL8797449 | 0.81 | LPAR1 (0.44) | LPAR1KMT2ALMNAHDAC4HDAC7 | |
| SCHEMBL8798173 | 0.80 | TP53 (0.47) | KMT2ALMNAHDAC4HDAC7HDAC5 | |
| SCHEMBL8797662 | 0.79 | LPAR1 (0.46) | LPAR1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL8796912 | 0.78 | TP53 (0.41) | LPAR1KMT2ALMNAHDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |