Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797684 | 0.80 | LPAR1 (0.43) | MEN1KMT2ASMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL14124766 | 0.77 | EDNRB (0.50) | EDNRBEDNRAALDH1A1POLBCYP1A2 | |
| SCHEMBL2989515 | 0.70 | HDAC4 (0.66) | MEN1KMT2AEDNRASMN1; SMN2LMNA | |
| SCHEMBL31613807 | 0.70 | HDAC4 (0.66) | MEN1KMT2AEDNRASMN1; SMN2LMNA | |
| SCHEMBL11789597 | 0.69 | SCN2A (0.44) | MEN1KMT2AEDNRBEDNRAALDH1A1 | |
| Hydrochloric Acid SCHEMBL2982836 | 0.69 | HDAC4 (0.64) | MEN1KMT2AEDNRASMN1; SMN2LMNA | |
| SCHEMBL14124713 | 0.69 | EDNRB (0.47) | MEN1KMT2AEDNRBEDNRAALDH1A1 | |
| SCHEMBL40500 | 0.68 | HDAC3 (0.59) | MEN1KMT2AEDNRBEDNRAPOLB | |
| Benzene SCHEMBL28538497 | 0.68 | HDAC3 (0.59) | MEN1KMT2AEDNRBEDNRAPOLB | |
| SCHEMBL30001332 | 0.68 | HDAC3 (0.59) | MEN1KMT2AEDNRBEDNRAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |