Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 10/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797272 | 0.91 | TP53 (0.45) | TP53LPAR1TBXA2RKMT2ANLRP3 | |
| SCHEMBL8797028 | 0.90 | TBXA2R (0.38) | TP53LPAR1TBXA2RKMT2ANLRP3 | |
| SCHEMBL8797139 | 0.89 | TP53 (0.37) | TP53LPAR1TBXA2RKMT2ANLRP3 | |
| SCHEMBL8797835 | 0.88 | TP53 (0.38) | TP53TBXA2RKMT2AMAPTTBXAS1 | |
| SCHEMBL8798008 | 0.85 | LPAR1 (0.46) | TP53LPAR1NLRP3CYP3A4 | |
| SCHEMBL8797529 | 0.82 | TP53 (0.46) | TP53LPAR1KMT2ANLRP3MAPT | |
| SCHEMBL8799023 | 0.81 | LPAR1 (0.38) | TP53LPAR1TBXA2RKMT2ANLRP3 | |
| SCHEMBL8797886 | 0.81 | LPAR1 (0.42) | TP53LPAR1TBXA2RKMT2ANLRP3 | |
| SCHEMBL8797777 | 0.81 | TP53 (0.52) | TP53TBXA2RKMT2AMAPTNPSR1 | |
| SCHEMBL8798069 | 0.81 | TP53 (0.61) | TP53TBXA2RKMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |