Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 1.00 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317332 | 0.89 | EGFR (1.00) | EGFR | |
| SCHEMBL8321437 | 0.89 | EGFR (0.80) | EGFRBRAFCSNK2A1 | |
| SCHEMBL8318038 | 0.87 | EGFR (0.77) | EGFRBRAFCSNK2A1 | |
| SCHEMBL8316766 | 0.85 | EGFR (0.74) | EGFRBRAFCSNK2A1 | |
| SCHEMBL7578986 | 0.85 | EGFR (0.73) | EGFRBRAF | |
| SCHEMBL8318613 | 0.84 | EGFR (0.73) | EGFRBRAF | |
| SCHEMBL8320030 | 0.83 | EGFR (0.71) | EGFRBRAF | |
| SCHEMBL8317938 | 0.82 | EGFR (0.73) | EGFR | |
| SCHEMBL8317682 | 0.82 | EGFR (0.70) | EGFRBRAF | |
| SCHEMBL8320643 | 0.81 | EGFR (0.72) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |