⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15903643 | 0.69 | — | — | |
| SCHEMBL15561244 | 0.64 | CA1 (0.33) | — | |
| SCHEMBL4159571 | 0.62 | — | — | |
| SCHEMBL11425305 | 0.60 | — | — | |
| SCHEMBL746665 | 0.57 | — | — | |
| SCHEMBL29176403 | 0.56 | CA1 (0.33) | — | |
| SCHEMBL3520833 | 0.56 | — | — | |
| SCHEMBL2405993 | 0.56 | — | — | |
| SCHEMBL18032691 | 0.55 | GSK3A (0.30) | — | |
| SCHEMBL447698 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708778-B1 | IMIDAZO[1,2-A]PYRAZIN-4-ONE DERIVATIVES FOR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | RHONE POULENC RORER SA (FR) | 1997-02-05 | — | — | EP | disclosed |
| EP-0708778-A1 | IMIDAZO[1,2-A]PYRAZIN-4-ONE DERIVATIVES FOR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | RHONE POULENC RORER SA (FR) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002602-A1 | IMIDAZO(1,2-A)PYRAZIN-4-ONE DERIVATIVES FOR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-01-26 | — | — | WO | disclosed |