Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798658 | 0.85 | PARP1 (0.44) | PARP1PIM1PIM2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8800315 | 0.84 | PARP1 (0.43) | PARP1PIM1PIM2CYP3A4 | |
| SCHEMBL8798434 | 0.83 | PARP1 (0.48) | PARP1 | |
| Hydrochloric Acid SCHEMBL9484143 | 0.82 | PARP1 (0.47) | PARP1 | |
| Hydrochloric Acid SCHEMBL8800976 | 0.82 | PARP1 (0.47) | PARP1 | |
| Hydrochloric Acid SCHEMBL8801079 | 0.82 | PARP1 (0.47) | PARP1 | |
| SCHEMBL8798897 | 0.81 | PARP1 (0.44) | PARP1PARP3PIM1PIM2 | |
| Hydrochloric Acid SCHEMBL8799095 | 0.80 | PARP1 (0.43) | PARP1PARP3PIM1PIM2 | |
| SCHEMBL8800588 | 0.80 | PARP1 (0.45) | PARP1PIM1PIM2 | |
| SCHEMBL8800208 | 0.78 | PARP1 (0.50) | PARP1PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525584-B1 | 6-Oxo-azepinoindole derivatives, process and intermediates for their preparation and medicaments containing them | SOLVAY PHARM GMBH (DE) | 1997-12-10 | — | — | EP | disclosed |
| US-5272143-A | 6-oxoazepinoindole compounds, and pharmaceutical compositions containing them | KALI-CHEMIE PHARMA GMBH (DE) | 1993-12-21 | — | — | US | disclosed |
| EP-0525584-A1 | 6-Oxo-azepinoindole derivatives, process and intermediates for their preparation and medicaments containing them | Kali-Chemie Pharma GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |