Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8140395 | 0.93 | CYSLTR1 (0.54) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8140403 | 0.89 | PDE10A (0.46) | CYSLTR1CYSLTR2PDE10AALOX5FFAR1 | |
| SCHEMBL8144381 | 0.82 | CYSLTR1 (0.47) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8139281 | 0.77 | GPBAR1 (0.49) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8801425 | 0.76 | PDE10A (0.48) | CYSLTR1CYSLTR2PDE10AALOX5FFAR1 | |
| SCHEMBL8801178 | 0.75 | GPBAR1 (0.51) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8144944 | 0.71 | CYSLTR1 (0.52) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8139297 | 0.71 | PDE10A (0.45) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL8801213 | 0.70 | GPBAR1 (0.53) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL8801970 | 0.70 | CYSLTR1 (0.58) | GPBAR1CYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799826-A1 | Heteroaryl substituted phenylene derivatives, their preparation and their use as leukotriene receptor antagonists | KOWA CO. LTD. (JP) | 1997-10-08 | — | — | EP | disclosed |