Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083408 | 0.80 | NOTUM (0.57) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL8785820 | 0.75 | NOTUM (0.51) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL7086213 | 0.74 | HTR2C (0.59) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL8530059 | 0.69 | HTR2A (0.57) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL7373998 | 0.69 | NOTUM (0.59) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL7479611 | 0.69 | NOTUM (0.59) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL8526767 | 0.68 | NOTUM (0.49) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL29803331 | 0.68 | NOTUM (0.60) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL22462287 | 0.68 | NOTUM (0.60) | NOTUMCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL30038606 | 0.67 | NOTUM (0.78) | NOTUMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807104-A2 | HETEROCYCLIC COMPOUNDS POSSESSING 5HT 2C? RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1997-11-19 | — | — | EP | disclosed |