Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800859 | 0.94 | GPBAR1 (0.53) | GPBAR1MAOAMAOBPDE10ACYSLTR1 | |
| SCHEMBL8801126 | 0.92 | CYSLTR1 (0.59) | GPBAR1MAOAMAOBCYSLTR1CYSLTR2 | |
| SCHEMBL8801736 | 0.85 | CYSLTR1 (0.58) | GPBAR1MAOAMAOBCYSLTR1CYSLTR2 | |
| SCHEMBL8800294 | 0.83 | GPBAR1 (0.53) | GPBAR1MAOAMAOBPDE10ACYSLTR1 | |
| SCHEMBL8801320 | 0.81 | GPBAR1 (0.54) | GPBAR1PDE10ACYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL8801200 | 0.80 | GPBAR1 (0.53) | GPBAR1PDE10ACYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL8801178 | 0.78 | GPBAR1 (0.51) | GPBAR1PDE10ACYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL8803327 | 0.76 | CYSLTR1 (0.57) | GPBAR1MAOAMAOBCYSLTR1CYSLTR2 | |
| SCHEMBL3271439 | 0.73 | CYSLTR1 (0.76) | GPBAR1PDE10ACYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL27716196 | 0.73 | GPBAR1 (0.74) | GPBAR1PDE10ACYSLTR1CYSLTR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799826-A1 | Heteroaryl substituted phenylene derivatives, their preparation and their use as leukotriene receptor antagonists | KOWA CO. LTD. (JP) | 1997-10-08 | — | — | EP | disclosed |