Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 7/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 5/20 | 0.43 |
| ▸ | DRD5 | P21918 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189450 | 0.85 | PDE1A (0.53) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL2410839 | 0.84 | PDE1A (0.66) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL2411059 | 0.83 | PDE1A (0.59) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL2409801 | 0.82 | PDE1A (0.57) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL8803918 | 0.82 | PDE1A (0.56) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL2411634 | 0.81 | PDE1A (0.52) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL4185641 | 0.81 | PDE1A (0.51) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL2415828 | 0.81 | PDE1A (0.53) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL4187908 | 0.81 | PDE1A (0.56) | PDE1APDE1BPDE4APDE4BPDE4C | |
| SCHEMBL4183665 | 0.80 | PDE1A (0.53) | PDE1APDE1BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526840-B1 | Condensed naphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1997-10-22 | — | — | EP | disclosed |
| US-5281610-A | Pyrazolonaphthyridine pharmaceuticals | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| EP-0526840-A1 | Condensed naphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-02-10 | — | — | EP | disclosed |