Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 10/20 | 1.00 |
| ▸ | LMNA | P02545 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.78 |
| ▸ | TP53 | P04637 | 7/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.78 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10280607 | 0.93 | TSHR (0.87) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL21643939 | 0.87 | TSHR (1.00) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL12470138 | 0.86 | TSHR (0.76) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL12698422 | 0.81 | TSHR (0.69) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL880277 | 0.81 | TSHR (0.69) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL12469684 | 0.81 | SMN1; SMN2 (1.00) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL29433738 | 0.81 | SMN1; SMN2 (1.00) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL12698265 | 0.81 | SMN1; SMN2 (1.00) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL17226016 | 0.81 | SMN1; SMN2 (1.00) | TSHRLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL29433753 | 0.81 | SMN1; SMN2 (1.00) | TSHRLMNAALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440705-B2 | 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-2-one or 2,3,4,6,7,8-hexahydro-1H-cyclopenta[g]quinolin-2-one; Alzheimer's disease | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |