Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130886 | 0.84 | FGFR1 (0.77) | FGFR1KMT2APDGFRBPDGFRAMAPT | |
| SCHEMBL8129187 | 0.77 | FGFR1 (0.66) | FGFR1KMT2APDGFRBPDGFRAMAPT | |
| SCHEMBL23365207 | 0.75 | NPC1 (0.50) | KMT2AMAPTHTTLMNANPC1 | |
| SCHEMBL30489098 | 0.73 | F2RL3 (0.48) | KMT2AMAPTMAPK1NPC1RAB9A | |
| SCHEMBL5619571 | 0.71 | FGFR1 (1.00) | FGFR1KMT2APDGFRBPDGFRAMAPT | |
| SCHEMBL264291 | 0.71 | KMT2A (0.73) | FGFR1KMT2AMAPTTP53TSHR | |
| SCHEMBL30488020 | 0.71 | KMT2A (0.73) | FGFR1KMT2AMAPTTP53TSHR | |
| SCHEMBL8135363 | 0.71 | MAPT (0.61) | FGFR1KMT2APDGFRBPDGFRAMAPT | |
| SCHEMBL8122474 | 0.71 | KMT2A (0.59) | FGFR1KMT2APDGFRBPDGFRAMAPT | |
| SCHEMBL24457853 | 0.70 | FGFR1 (0.40) | FGFR1KMT2AHTTMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790997-A2 | 6-ARYL PYRIDO( 2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1997-08-27 | — | — | EP | claimed |