Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGFRL1 | Q5TC84 | 20/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 17/20 | 0.78 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.73 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.67 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880399 | 0.87 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL10290872 | 0.87 | OGFRL1 (0.66) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL854042 | 0.85 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL19836645 | 0.82 | OGFRL1 (0.78) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL17807896 | 0.81 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL854049 | 0.81 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL852371 | 0.81 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL852370 | 0.81 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL854048 | 0.81 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL852144 | 0.81 | OGFRL1 (1.00) | OGFRL1OPRK1OPRM1OPRD1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2537844-A1 | Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof | Purdue Pharma L.P. (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2324013-B1 | SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA LP (US) | 2012-09-19 | — | — | EP | disclosed |
| EP-2433937-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433936-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010010458-A1 | SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (US) | 2010-01-28 | — | — | WO | disclosed |