Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807050 | 0.95 | ABCB1 (0.45) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL8809632 | 0.92 | BCHE (0.44) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL8807343 | 0.90 | ABCB1 (0.42) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL8809566 | 0.90 | BCHE (0.43) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL8807284 | 0.89 | ABCG2 (0.43) | ABCB1ABCG2TP53MAPTMEN1 | |
| SCHEMBL8808101 | 0.89 | BCHE (0.43) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL8806985 | 0.88 | ABCB1 (0.42) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL8807951 | 0.87 | BCHE (0.45) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL8807055 | 0.87 | ABCG2 (0.43) | ABCB1ABCG2TP53MAPTMEN1 | |
| SCHEMBL8790168 | 0.86 | ABCG2 (0.62) | ABCB1ABCG2OPRM1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |