Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807066 | 0.95 | ABCG2 (0.42) | ABCG2ABCB1KLKB1SMN1; SMN2MAOB | |
| SCHEMBL8809649 | 0.92 | MAPT (0.40) | ABCG2ABCB1SMN1; SMN2MAOBADORA2B | |
| SCHEMBL8807360 | 0.90 | ABCB1 (0.39) | ABCG2ABCB1KLKB1SMN1; SMN2MAOB | |
| SCHEMBL8809583 | 0.90 | MAPT (0.40) | ABCG2ABCB1SMN1; SMN2MAOBADORA2B | |
| SCHEMBL8808107 | 0.89 | MAPT (0.39) | ABCG2ABCB1SMN1; SMN2MAOBADORA2B | |
| SCHEMBL8806996 | 0.88 | ABCB1 (0.38) | ABCG2ABCB1KLKB1SMN1; SMN2MAOB | |
| SCHEMBL8807960 | 0.87 | MAPT (0.43) | ABCG2ABCB1SMN1; SMN2MAOBADORA2B | |
| SCHEMBL8806947 | 0.86 | ABCB1 (0.39) | ABCG2ABCB1KLKB1SMN1; SMN2MAOB | |
| SCHEMBL8808377 | 0.82 | MAPT (0.40) | SMN1; SMN2MAOBADORA2BMAPTTP53 | |
| SCHEMBL8807284 | 0.81 | ABCG2 (0.43) | ABCG2ABCB1KLKB1SMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |