Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808264 | 0.89 | ADORA1 (0.59) | ADORA1IGF1RMAPK1EGFRKDM4E | |
| SCHEMBL9773260 | 0.84 | ADORA1 (0.52) | ADORA1IGF1RMAPK1EGFRKMT2A | |
| SCHEMBL8810075 | 0.83 | ADORA1 (0.44) | ADORA1IGF1RMAPK1EGFRKMT2A | |
| SCHEMBL8808815 | 0.82 | ADORA1 (0.46) | ADORA1IGF1RMAPK1EGFRKMT2A | |
| SCHEMBL8808388 | 0.81 | ADORA1 (0.42) | ADORA1IGF1RMAPK1EGFRKMT2A | |
| SCHEMBL8808083 | 0.80 | ADORA1 (0.73) | ADORA1IGF1RMAPK1KMT2ALMNA | |
| SCHEMBL8808962 | 0.78 | ADORA1 (0.54) | ADORA1IGF1RMAPK1EGFRKMT2A | |
| SCHEMBL8812594 | 0.77 | ADORA1 (0.48) | ADORA1IGF1RMAPK1EGFRKMT2A | |
| SCHEMBL8808435 | 0.76 | PDE4B (0.49) | ADORA1IGF1RMAPK1EGFRKMT2A | |
| SCHEMBL8810287 | 0.75 | ADORA1 (0.44) | ADORA1IGF1RMAPK1EGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379979-B1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-03-19 | — | — | EP | disclosed |
| US-5155114-A | Treating or preventing renal toxicity, nephrosis, nephritis | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0379979-A1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |