Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | PDE7A | Q13946 | 18/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854148 | 0.75 | PDE7A (0.88) | PDE7A | |
| SCHEMBL854150 | 0.75 | PDE7A (0.88) | PDE7A | |
| SCHEMBL13076083 | 0.74 | PDE7A (0.65) | PDE7A | |
| Bicarbonate SCHEMBL14775793 | 0.74 | PDE7A (0.84) | PDE7A | |
| Bicarbonate SCHEMBL14775802 | 0.74 | PDE7A (0.84) | PDE7A | |
| SCHEMBL854824 | 0.73 | PDE7A (0.92) | PDE7A | |
| SCHEMBL880739 | 0.73 | PDE7A (0.67) | PDE7A | |
| SCHEMBL853140 | 0.72 | PDE7A (0.69) | PDE7A | |
| SCHEMBL880652 | 0.71 | PDE7A (0.85) | PDE7A | |
| SCHEMBL12808500 | 0.71 | PDE7A (0.75) | PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433943-A1 | Thienopyrazole derivatives having PDE7 inhibitory activity | Daiichi Sankyo Company, Limited (JP) | 2012-03-28 | — | — | EP | disclosed |