Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.40 |
| ▸ | FABP7 | O15540 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29855110 | 0.87 | FABP5 (0.44) | KMT2AFABP5FABP7EPHX2ALDH1A1 | |
| SCHEMBL25173108 | 0.87 | FABP5 (0.44) | KMT2AFABP5FABP7EPHX2ALDH1A1 | |
| SCHEMBL8804802 | 0.87 | FABP5 (0.44) | KMT2AFABP5FABP7EPHX2ALDH1A1 | |
| SCHEMBL13335430 | 0.84 | KMT2A (0.42) | KMT2AFABP5FABP7EPHX2POLB | |
| SCHEMBL23517944 | 0.83 | KMT2A (0.45) | KMT2AFABP5FABP7EPHX2CASP3 | |
| SCHEMBL15083099 | 0.81 | PPARG (0.43) | KMT2AFABP5FABP7EPHX2ALDH1A1 | |
| SCHEMBL30744235 | 0.81 | PPARG (0.43) | KMT2AFABP5FABP7EPHX2ALDH1A1 | |
| SCHEMBL29540316 | 0.81 | PPARG (0.43) | KMT2AFABP5FABP7EPHX2ALDH1A1 | |
| SCHEMBL16288980 | 0.81 | PPARG (0.43) | KMT2AFABP5FABP7EPHX2ALDH1A1 | |
| SCHEMBL31000561 | 0.81 | KMT2A (0.38) | KMT2AFABP5FABP7EPHX2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537269-B1 | IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMA (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5665774-A | TREATMENT OF AUTOIMMUNE DISEASES | VERTEX PHARMACEUTICALS INCORPORATED | 1997-09-09 | — | — | US | disclosed |
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0537269-A1 | NOVEL IMMUNOSUPPRESSIVE COMPOUNDS. | VERTEX PHARMA (US) | 1993-04-21 | — | — | EP | disclosed |
| US-5192773-A | Isomerase inhibitor | VERTEX PHARMACEUTICALS, INC. (US) | 1993-03-09 | — | — | US | disclosed |