Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810287 | 0.89 | ADORA1 (0.44) | ADORA1MAPK1AKT1IGF1RKDM4E | |
| SCHEMBL8808477 | 0.74 | ADORA1 (0.53) | ADORA1MAPK1AKT1IGF1RKDM4E | |
| SCHEMBL8808264 | 0.72 | ADORA1 (0.59) | ADORA1MAPK1AKT1IGF1RKDM4E | |
| SCHEMBL8807266 | 0.72 | ADORA1 (0.88) | ADORA1MAPK1AKT1IGF1RKDM4E | |
| SCHEMBL8809607 | 0.71 | IGF1R (0.47) | ADORA1MAPK1AKT1IGF1REGFR | |
| SCHEMBL8807259 | 0.71 | ADORA1 (0.57) | ADORA1MAPK1AKT1IGF1RKDM4E | |
| SCHEMBL8808089 | 0.70 | ADORA1 (0.64) | ADORA1MAPK1AKT1IGF1RKDM4E | |
| SCHEMBL8809176 | 0.69 | ADORA1 (0.52) | ADORA1MAPK1AKT1IGF1RKDM4E | |
| SCHEMBL2641189 | 0.69 | ADORA1 (1.00) | ADORA1MAPK1IGF1RKDM4EHSD17B10 | |
| SCHEMBL8807647 | 0.68 | ADORA1 (0.94) | ADORA1MAPK1IGF1RKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379979-B1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-03-19 | — | — | EP | disclosed |
| US-5155114-A | Treating or preventing renal toxicity, nephrosis, nephritis | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-4985444-A | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0379979-A1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |