Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14502354 | 0.87 | AKT1 (0.65) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL8810466 | 0.83 | MAPK14 (0.78) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL8807637 | 0.82 | AKT1 (0.51) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL8809320 | 0.82 | AKT1 (0.54) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL8811450 | 0.79 | MAPK14 (0.57) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL14810260 | 0.79 | MAPK14 (0.60) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL14502340 | 0.78 | AKT1 (0.60) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL8812720 | 0.78 | AKT1 (0.50) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL8807304 | 0.78 | MAPK14 (0.56) | MAPK14ADORA1EGFRRAF1ADORA3 | |
| SCHEMBL8811319 | 0.77 | AKT1 (0.52) | MAPK14ADORA1EGFRRAF1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379979-B1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-03-19 | — | — | EP | disclosed |
| US-5155114-A | Treating or preventing renal toxicity, nephrosis, nephritis | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-4985444-A | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0379979-A1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |