Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPM1 | P06748 | 1/20 | 0.67 |
| ▸ | PARP1 | P09874 | 9/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811262 | 0.89 | PARP1 (0.58) | NPM1PARP1CNR2POLBSIRT1 | |
| SCHEMBL8685538 | 0.88 | PARP1 (0.63) | NPM1PARP1CNR2POLBSIRT1 | |
| SCHEMBL8808565 | 0.88 | PARP1 (0.76) | NPM1PARP1CNR2POLBSIRT1 | |
| SCHEMBL8685201 | 0.88 | PARP1 (0.76) | NPM1PARP1CNR2POLBSIRT1 | |
| SCHEMBL8812780 | 0.87 | PARP1 (0.62) | NPM1PARP1CNR2POLBSIRT1 | |
| SCHEMBL8810595 | 0.87 | NPM1 (0.50) | NPM1PARP1CNR2POLBHTT | |
| SCHEMBL8809718 | 0.86 | PARP1 (0.77) | NPM1PARP1CNR2SIRT1SIRT5 | |
| SCHEMBL8810780 | 0.84 | PARP1 (0.66) | NPM1PARP1CNR2POLBSIRT1 | |
| SCHEMBL3140242 | 0.83 | NPM1 (0.82) | NPM1PARP1CNR2POLBSIRT1 | |
| SCHEMBL3140251 | 0.83 | NPM1 (0.82) | NPM1PARP1CNR2POLBSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |