Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.57 |
| ▸ | CA1 | P00915 | 6/20 | 0.57 |
| ▸ | CA2 | P00918 | 6/20 | 0.57 |
| ▸ | CA9 | Q16790 | 6/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | TACR3 | P29371 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808186 | 0.91 | CYP3A4 (0.64) | CYP3A4TACR3MAPTTP53KDM4E | |
| SCHEMBL8808572 | 0.90 | CA12 (0.56) | CA12CA1CA2CA9CYP3A4 | |
| SCHEMBL8809319 | 0.89 | MEN1 (0.61) | CA12CA1CA2CA9CYP3A4 | |
| SCHEMBL8830721 | 0.87 | CYP3A4 (0.65) | CYP3A4TACR3MAPTTP53KDM4E | |
| SCHEMBL8808583 | 0.83 | CA12 (0.55) | CA12CA1CA2CA9CYP3A4 | |
| SCHEMBL8808178 | 0.81 | MAPT (0.64) | CYP3A4TACR3MAPTTP53KDM4E | |
| SCHEMBL8809314 | 0.80 | MEN1 (0.60) | CA12CA1CA2CA9CYP3A4 | |
| SCHEMBL8807108 | 0.80 | MEN1 (0.61) | CA12CA1CA2CA9CYP3A4 | |
| SCHEMBL8806661 | 0.78 | MAPT (0.66) | CYP3A4TACR3MAPTTP53KDM4E | |
| SCHEMBL28844500 | 0.78 | TACR3 (0.76) | CA12CA1CA2CA9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |