Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.60 |
| ▸ | P4HB | P07237 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1373077 | 0.98 | MEN1 (0.64) | MEN1KMT2AGFERHTR1AGAA | |
| SCHEMBL4393525 | 0.86 | MEN1 (0.64) | MEN1KMT2AGFERHTR1AGAA | |
| SCHEMBL10770280 | 0.86 | MEN1 (0.64) | MEN1KMT2AGFERHTR1AGAA | |
| SCHEMBL5011458 | 0.85 | KMT2A (0.75) | MEN1KMT2AGFERHTR1ADRD2 | |
| SCHEMBL7370493 | 0.83 | MAPT (0.57) | MEN1KMT2AGFERPOLBREV1 | |
| SCHEMBL13234976 | 0.83 | MAPT (0.67) | MEN1KMT2AHTR1AGAAPOLB | |
| SCHEMBL3161414 | 0.82 | KMT2A (0.67) | MEN1KMT2AGFERHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL1373869 | 0.82 | GFER (0.67) | MEN1KMT2AGFERDRD2TSHR | |
| SCHEMBL26373091 | 0.82 | S1PR1 (0.61) | MEN1KMT2AGFERGAAREV1 | |
| SCHEMBL2881604 | 0.82 | MAPT (0.66) | MEN1KMT2AHTR1AGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717733-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| US-5686480-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0717733-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007262-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-16 | — | — | WO | disclosed |