Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 4/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855319 | 0.81 | SYK (0.39) | FGFR4SYKRAF1BRAFFGFR1 | |
| SCHEMBL855318 | 0.81 | SYK (0.39) | FGFR4SYKRAF1BRAFFGFR1 | |
| SCHEMBL10043818 | 0.72 | SYK (0.54) | SYKRAF1BRAFFGFR1SRC | |
| SCHEMBL854800 | 0.71 | SYK (0.41) | FGFR4SYKFGFR1SRC | |
| SCHEMBL854801 | 0.71 | SYK (0.41) | FGFR4SYKFGFR1SRC | |
| SCHEMBL12400045 | 0.70 | SRC (0.36) | SYKRAF1BRAFFGFR1SRC | |
| SCHEMBL10043820 | 0.70 | GRM1 (0.44) | FGFR4SYKRAF1BRAFFGFR1 | |
| SCHEMBL10043819 | 0.70 | SYK (0.43) | FGFR4SYKRAF1BRAFFGFR1 | |
| SCHEMBL854684 | 0.69 | SRC (0.44) | FGFR4FGFR1SRC | |
| SCHEMBL10272342 | 0.68 | SYK (0.41) | FGFR4SYKFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252612-B1 | HETEROCYCLIC COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS | IRM LLC (BM) | 2012-03-28 | — | — | EP | disclosed |