Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809467 | 1.00 | ADORA2A (0.47) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL8811759 | 0.84 | ADORA2A (0.45) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL9197850 | 0.83 | ADORA2A (0.51) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL9197859 | 0.83 | ADORA2A (0.51) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL9753124 | 0.83 | EGFR (0.38) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL9753122 | 0.83 | EGFR (0.38) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL15489225 | 0.82 | ADORA2A (0.35) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL7294663 | 0.81 | ADORA2A (0.56) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL7294668 | 0.81 | ADORA2A (0.56) | ADORA2AADORA2BADORA1ADORA3EGFR | |
| SCHEMBL9314182 | 0.79 | ADORA2A (0.54) | ADORA2AADORA2BADORA1ADORA3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379979-B1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-03-19 | — | — | EP | disclosed |
| US-5155114-A | Treating or preventing renal toxicity, nephrosis, nephritis | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-4985444-A | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0379979-A1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |