Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492232 | 0.84 | TACR1 (0.43) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL19534291 | 0.84 | IDO1 (0.46) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL7012505 | 0.80 | TACR1 (0.43) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL2916974 | 0.80 | TSHR (0.40) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL21150760 | 0.80 | TACR1 (0.43) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL21753397 | 0.79 | NPC1 (0.43) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL21151186 | 0.78 | BACE1 (0.45) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL3245801 | 0.77 | KMT2A (0.56) | ALDH1A1GPR119SMN1; SMN2TACR1 | |
| SCHEMBL8811737 | 0.77 | TSHR (0.38) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL4136918 | 0.76 | KDM4E (0.44) | KDM4EMAPTTHRBDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |