Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809702 | 1.00 | PARP1 (0.82) | PARP1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL8690727 | 0.92 | PARP1 (0.79) | PARP1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL8812784 | 0.92 | PARP1 (0.79) | PARP1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL8809710 | 0.90 | PARP1 (1.00) | PARP1SMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL8688039 | 0.90 | PARP1 (1.00) | PARP1SMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL1248861 | 0.88 | PARP1 (0.83) | PARP1SMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL12891974 | 0.88 | PARP1 (0.83) | PARP1SMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL1248859 | 0.88 | PARP1 (0.83) | PARP1SMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL8810231 | 0.88 | PARP1 (0.79) | PARP1SMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL8810227 | 0.88 | PARP1 (0.79) | PARP1SMN1; SMN2ALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |