Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808612 | 0.81 | KDM4E (0.42) | KDM4ECMA1ALDH1A1DRD2DRD3 | |
| SCHEMBL21136256 | 0.81 | KDM4E (0.44) | KDM4ENOTUMCMA1ALDH1A1HSD17B10 | |
| SCHEMBL2939131 | 0.76 | BPTF (0.40) | KDM4EALDH1A1ACHECYP3A4CYP2D6 | |
| SCHEMBL2940165 | 0.75 | BPTF (0.39) | KDM4EALDH1A1ACHECYP3A4CYP2D6 | |
| SCHEMBL2939391 | 0.74 | MAPT (0.41) | KDM4ENOTUMALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL7408420 | 0.74 | NOTUM (0.60) | NOTUM | |
| SCHEMBL14320304 | 0.74 | MAPT (0.41) | KDM4EALDH1A1ADRA2CHSD17B10USP2 | |
| SCHEMBL7801882 | 0.73 | NOTUM (0.51) | KDM4ENOTUMALDH1A1ACHEADRA1D | |
| SCHEMBL6393391 | 0.72 | CMA1 (0.49) | KDM4ECMA1ALDH1A1HTR1AADRA2A | |
| SCHEMBL2940577 | 0.71 | NOTUM (0.44) | NOTUMBPTFMAPTITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777666-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006094-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1996-02-29 | — | — | WO | disclosed |