Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433319 | 0.92 | EPHX1 (0.50) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL4433316 | 0.92 | EPHX1 (0.50) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL20196991 | 0.89 | TDP1 (0.47) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL12648114 | 0.89 | EPHX1 (0.55) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL17235806 | 0.84 | KMT2A (0.46) | EPHX1TDP1KMT2ACTSSCTSK | |
| SCHEMBL27808853 | 0.83 | EPHX1 (0.50) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL5030185 | 0.83 | TDP1 (0.51) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL5030182 | 0.83 | TDP1 (0.51) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL6014890 | 0.82 | BTK (0.54) | EPHX1TDP1KMT2AMEN1GAA | |
| SCHEMBL23236537 | 0.81 | EPHX1 (0.49) | EPHX1TDP1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433926-A1 | Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes | Nabriva Therapeutics AG (AT) | 2012-03-28 | — | — | EP | disclosed |