Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 5/20 | 0.72 |
| ▸ | EGFR | P00533 | 5/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.67 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 3/20 | 0.63 |
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.63 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.63 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.63 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.63 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.63 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.63 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.63 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8933873 | 0.99 | FGFR2 (0.70) | FGFR2EGFRRIPK2EPHB2PDGFRA | |
| SCHEMBL31123432 | 0.90 | EGFR (0.69) | FGFR2EGFRRIPK2EPHB2PDGFRA | |
| SCHEMBL8501712 | 0.90 | EGFR (0.74) | FGFR2EGFRRIPK2PDGFRAGAK | |
| Hydrochloric Acid SCHEMBL8933671 | 0.89 | EGFR (0.67) | FGFR2EGFRRIPK2EPHB2PDGFRA | |
| SCHEMBL24143588 | 0.89 | FGFR2 (0.81) | FGFR2EGFRRIPK2PDGFRAGAK | |
| SCHEMBL15607618 | 0.89 | FGFR2 (0.58) | FGFR2EGFRRIPK2EPHB2PDGFRA | |
| SCHEMBL1387146 | 0.86 | EGFR (0.62) | FGFR2EGFRRIPK2EPHB2PDGFRA | |
| Hydrochloric Acid SCHEMBL8933904 | 0.85 | EGFR (0.62) | FGFR2EGFRRIPK2EPHB2PDGFRA | |
| Hydrochloric Acid SCHEMBL8808103 | 0.85 | EGFR (0.61) | FGFR2EGFRRIPK2EPHB2PDGFRA | |
| SCHEMBL30017094 | 0.84 | FGFR2 (0.61) | FGFR2EGFRRIPK2PDGFRAGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10548897-B2 | KSR antagonists | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2020-02-04 | — | — | US | disclosed |
| WO-2016168704-A1 | KSR ANTAGONISTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-10-20 | — | — | WO | disclosed |
| EP-0782570-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009294-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10548897-B2 | KSR antagonists | KSR1, KSR2, KRAS | FGFR2 805/4885EGFR 182/4885RIPK2 1014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.