Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079723 | 1.00 | POLB (0.57) | POLBMAPTKMT2AMEN1CA12 | |
| SCHEMBL4960442 | 0.82 | MAPT (0.55) | POLBMAPTKMT2AMEN1NPC1 | |
| SCHEMBL9176622 | 0.82 | POLB (0.50) | POLBMAPTKMT2AMEN1CA12 | |
| SCHEMBL9176618 | 0.82 | POLB (0.50) | POLBMAPTKMT2AMEN1CA12 | |
| SCHEMBL8811773 | 0.81 | TP53 (0.54) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9081774 | 0.81 | TP53 (0.54) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL11497034 | 0.78 | MEN1 (0.51) | POLBMAPTKMT2AMEN1CA12 | |
| SCHEMBL11497036 | 0.78 | MEN1 (0.51) | POLBMAPTKMT2AMEN1CA12 | |
| SCHEMBL13529056 | 0.77 | DHODH (0.73) | KMT2AMEN1NPC1RAB9ADHODH | |
| SCHEMBL9079574 | 0.75 | MEN1 (0.54) | POLBMAPTKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1051074-C | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides pharmaceuticals containing these compounds and their use | HOECHST AG (DE) | 2000-04-05 | — | — | CN | disclosed |
| EP-0527736-B1 | ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS | HOECHST AG (DE) | 1997-04-16 | — | — | EP | disclosed |
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | disclosed |
| CN-1056684-A | Different azoles-4-carboxylic acid amides and hydroxy alkylidene Malonamide nitrile contains the medicine of these compounds and their application | HOECHST AG (DE) | 1991-12-04 | — | — | CN | disclosed |
| WO-1991017748-A1 | ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-28 | — | — | WO | disclosed |