Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | NPM1 | P06748 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809718 | 0.89 | PARP1 (0.77) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8810231 | 0.88 | PARP1 (0.79) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8810227 | 0.88 | PARP1 (0.79) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8812789 | 0.88 | SMN1; SMN2 (0.62) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8809713 | 0.88 | PARP1 (0.63) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8812780 | 0.87 | PARP1 (0.62) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8811994 | 0.87 | PARP1 (0.46) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8685538 | 0.86 | PARP1 (0.63) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8812826 | 0.85 | PARP1 (0.57) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8814205 | 0.84 | MAPT (0.70) | PARP1SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |