Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811438 | 1.00 | TSHR (0.64) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL8675577 | 0.97 | TSHR (0.67) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL4396246 | 0.97 | TSHR (0.67) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL8813133 | 0.95 | HTT (0.70) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL8814299 | 0.95 | HTT (0.70) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL23038721 | 0.92 | HTT (0.65) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL7635768 | 0.92 | HTT (0.65) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL7781141 | 0.92 | HTT (0.65) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL5698095 | 0.92 | TSHR (0.67) | TSHRHTTMEN1KMT2ATHRB | |
| SCHEMBL7851734 | 0.92 | HTT (0.65) | TSHRHTTMEN1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691319-A | ANTICARCINOGENIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0536936-B1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | SANKYO CO (JP) | 1996-08-14 | — | — | EP | disclosed |
| EP-0536936-A1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | Sankyo Company Limited (JP) | 1993-04-14 | — | — | EP | disclosed |