Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.76 |
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | MAX | P61244 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690614 | 1.00 | PARP1 (0.76) | PARP1IGF1RPIM1PIM2TTR | |
| SCHEMBL8813928 | 0.90 | PARP1 (0.64) | PARP1IGF1RPIM1PIM2TTR | |
| SCHEMBL8686629 | 0.90 | PARP1 (0.64) | PARP1IGF1RPIM1PIM2TTR | |
| SCHEMBL8685959 | 0.90 | PARP1 (0.66) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8685962 | 0.90 | PARP1 (0.66) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8687701 | 0.89 | PARP1 (0.76) | PARP1IGF1RPIM1PIM2TTR | |
| SCHEMBL8811679 | 0.89 | PARP1 (0.76) | PARP1IGF1RPIM1PIM2TTR | |
| SCHEMBL8691075 | 0.89 | PARP1 (0.60) | PARP1PIM1PIM2TTRMEN1 | |
| SCHEMBL8808793 | 0.89 | PARP1 (0.60) | PARP1PIM1PIM2TTRMEN1 | |
| SCHEMBL8812076 | 0.88 | PARP1 (0.60) | PARP1IGF1RPIM1TTRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |