Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 9/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808633 | 0.90 | PTGIR (0.54) | PTGIRTBXAS1 | |
| SCHEMBL8813299 | 0.90 | PTGIR (0.54) | PTGIRTBXAS1 | |
| SCHEMBL8412678 | 0.86 | PTGIR (0.57) | PTGIRCYP19A1TBXAS1 | |
| SCHEMBL8810714 | 0.86 | CYP19A1 (0.40) | PTGIRCYP19A1TBXAS1PDE3BPDE3A | |
| SCHEMBL8810712 | 0.86 | CYP19A1 (0.40) | PTGIRCYP19A1TBXAS1PDE3BPDE3A | |
| SCHEMBL8808705 | 0.84 | PTGIR (0.51) | PTGIRCYP19A1TBXAS1CYP11B1CYP11B2 | |
| SCHEMBL8809050 | 0.78 | CYP19A1 (0.38) | PTGIRCYP19A1TBXAS1PDE3BPDE3A | |
| SCHEMBL8813793 | 0.76 | PTGIR (0.39) | PTGIRTBXAS1 | |
| SCHEMBL8811347 | 0.76 | PTGIR (0.56) | PTGIRCYP19A1TBXAS1PDE3BPDE3A | |
| SCHEMBL8412675 | 0.76 | PTGIR (0.73) | PTGIRTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548949-B1 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO (JP) | 1997-09-17 | — | — | EP | claimed |
| EP-0548949-A2 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-30 | — | — | EP | claimed |
| EP-0548949-B1 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO (JP) | 1997-09-17 | — | — | EP | disclosed |
| US-5589496-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor agonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0548949-A2 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |