SCHEMBL8814320

SCHEMBL8814320

CCCCCc1ccc(-c2ccccn2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.64
CYP2D6 P10635 1/20 0.64
CYP19A1 P11511 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64
RAB9A P51151 6/20 0.54
MAPT P10636 4/20 0.54
SMN1; SMN2 Q16637 4/20 0.54
NPC1 O15118 4/20 0.54
STAT3 P40763 1/20 0.54
ATM Q13315 1/20 0.54
HSD11B1 P28845 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.52
CASP3 P42574 1/20 0.52
SENP8 Q96LD8 1/20 0.52
SENP7 Q9BQF6 1/20 0.52
SENP6 Q9GZR1 1/20 0.52
NFKB1 P19838 2/20 0.50
NFKB2 Q00653 2/20 0.50
RELA Q04206 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29002823 0.98 CYP1A2 (0.62) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
Ammonia Solution, Strong SCHEMBL28175142 0.98 CYP1A2 (0.62) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL3393437 0.98 CYP1A2 (0.62) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL19496902 0.98 CYP1A2 (0.62) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL2338244 0.97 CYP1A2 (0.60) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL14022965 0.95 CYP1A2 (0.66) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL3177333 0.88 CYP1A2 (0.60) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL16203117 0.87 CYP1A2 (0.50) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL18466596 0.86 CYP1A2 (0.58) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19
SCHEMBL2344310 0.86 CYP1A2 (0.58) CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9157255-A None JP disclosed
JP-9216868-A None JP disclosed
JP-9216868-A None JP disclosed
JP-H09216868-A 2-(4-ACYLPHENYL)PYRIDINE AND ITS OXIME SANKYO CO LTD 1997-08-19 JP disclosed
JP-H09216868-A 2-(4-ACYLPHENYL)PYRIDINE AND ITS OXIME SANKYO CO LTD 1997-08-19 JP disclosed
JP-H09157255-A PRODUCTION OF PHENYLPYRIDINE SANKYO CO LTD 1997-06-17 JP disclosed