Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 8/20 | 0.59 |
| ▸ | DHFR | P00374 | 3/20 | 0.48 |
| ▸ | ATIC | P31939 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8819923 | 0.93 | GART (0.60) | GARTDHFRATIC | |
| SCHEMBL8820483 | 0.90 | GART (0.60) | GARTDHFRATIC | |
| SCHEMBL9523254 | 0.88 | GART (0.62) | GARTDHFRATIC | |
| Lometrexol SCHEMBL12022771 | 0.88 | GART (0.75) | GARTDHFRATIC | |
| Lometrexol SCHEMBL9045915 | 0.88 | GART (0.75) | GARTDHFRATIC | |
| SCHEMBL9523528 | 0.88 | GART (0.59) | GARTDHFRATIC | |
| SCHEMBL9523303 | 0.88 | GART (0.59) | GARTDHFRATIC | |
| SCHEMBL9383637 | 0.87 | GART (0.57) | GARTDHFRATIC | |
| SCHEMBL8819504 | 0.87 | GART (0.55) | GARTDHFRATIC | |
| SCHEMBL9526912 | 0.87 | GART (0.59) | GARTDHFRATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049705-A1 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-12-31 | — | — | WO | claimed |