Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8821148 | 0.82 | FEN1 (0.50) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8821157 | 0.82 | CHEK1 (0.55) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8860089 | 0.82 | CHEK1 (0.48) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8821181 | 0.82 | CHEK1 (0.51) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8821152 | 0.82 | CHEK1 (0.45) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8821149 | 0.82 | CHEK1 (0.45) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8821162 | 0.82 | CHEK1 (0.45) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL12225071 | 0.80 | MAPK14 (0.49) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8821129 | 0.79 | MAP2K1 (0.45) | MAPK14AURKACHEK1DAPK3JAK2 | |
| SCHEMBL8821182 | 0.77 | MAPK14 (0.48) | MAPK14AURKACHEK1DAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631261-A | CENTRAL NERVOUS SYSTEM DISORDERS | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-20 | — | — | US | disclosed |
| EP-0673377-B1 | NEW TRIAZOLOQUINAZOLINES, THEIR PRODUCTION AND THEIR USE | BASF AG (DE) | 1997-02-26 | — | — | EP | disclosed |