Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8496461 | 1.00 | TDP1 (0.46) | TDP1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8825968 | 1.00 | TDP1 (0.46) | TDP1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8496467 | 1.00 | TDP1 (0.46) | TDP1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8826219 | 0.89 | MEN1 (0.53) | KMT2AMEN1 | |
| SCHEMBL8498369 | 0.89 | MEN1 (0.53) | KMT2AMEN1 | |
| SCHEMBL8826226 | 0.89 | MEN1 (0.53) | KMT2AMEN1 | |
| SCHEMBL8498367 | 0.89 | MEN1 (0.53) | KMT2AMEN1 | |
| SCHEMBL8826030 | 0.88 | KMT2A (0.46) | KMT2A | |
| SCHEMBL8493612 | 0.88 | KMT2A (0.46) | KMT2A | |
| SCHEMBL8493610 | 0.88 | KMT2A (0.46) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |