Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131044 | 0.90 | CASR (0.52) | CASRPOLBACP3HTTKDM4E | |
| SCHEMBL2341650 | 0.87 | POLB (0.61) | CASRPOLBACP3HTTMLNR | |
| SCHEMBL15131229 | 0.87 | POLB (0.61) | CASRPOLBACP3HTTMLNR | |
| SCHEMBL5193705 | 0.87 | POLB (0.61) | CASRPOLBACP3HTTMLNR | |
| Hydrochloric Acid SCHEMBL31355096 | 0.86 | CASR (0.60) | CASRPOLBACP3HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3067899 | 0.86 | CASR (0.60) | CASRPOLBACP3HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3082165 | 0.86 | CASR (0.60) | CASRPOLBACP3HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL607723 | 0.86 | CASR (0.60) | CASRPOLBACP3HTTSMN1; SMN2 | |
| SCHEMBL3348544 | 0.85 | CASR (0.46) | CASRCARM1PRMT6HRH3OPRM1 | |
| SCHEMBL2457278 | 0.85 | CASR (0.46) | CASRCARM1PRMT6HRH3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |