Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 5/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | BAX | Q07812 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039757 | 1.00 | TSHR (0.64) | TSHRKDM1ALTA4HCNR2CYP19A1 | |
| SCHEMBL8828040 | 1.00 | TSHR (0.64) | TSHRKDM1ALTA4HCNR2CYP19A1 | |
| SCHEMBL674815 | 0.91 | TSHR (0.54) | TSHRKDM1ALTA4HCNR2CYP19A1 | |
| SCHEMBL8524320 | 0.82 | TSHR (0.57) | TSHRKDM1ALTA4HCNR2ADRA1A | |
| SCHEMBL8524892 | 0.82 | TSHR (0.57) | TSHRKDM1ALTA4HCNR2ADRA1A | |
| SCHEMBL28467238 | 0.79 | TSHR (1.00) | TSHRCYP19A1ADRA1AHTR1AADRA1D | |
| SCHEMBL987488 | 0.79 | — | — | |
| SCHEMBL1943997 | 0.79 | — | — | |
| SCHEMBL21026 | 0.79 | — | — | |
| SCHEMBL30954854 | 0.78 | KDM1A (0.45) | TSHRKDM1ALTA4HCNR2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658904-A | COGNITION ACTIVATORS; BRAIN DISORDERS; ALZHEIMER*S DISEASE | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5612381-A | 1,2-ethanediol derivative and salt thereof process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-03-18 | — | — | US | disclosed |