SCHEMBL8828148

SCHEMBL8828148

COc1ccc(CCN(C)C(C)CCN)cc1OC

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.60
CYP1A2 P05177 2/20 0.59
CYP3A4 P08684 2/20 0.59
CYP2D6 P10635 2/20 0.59
KDM4E B2RXH2 5/20 0.58
ATM Q13315 2/20 0.58
BLM P54132 2/20 0.57
PMP22 Q01453 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.48
STAT3 P40763 1/20 0.48
CYP19A1 P11511 1/20 0.48
ALDH1A1 P00352 3/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
SMPD1 P17405 1/20 0.45
CYP2C9 P11712 1/20 0.44
POLB P06746 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
TAAR1 Q96RJ0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9153634 0.92 AOC3 (0.57) AOC3CYP1A2CYP3A4CYP2D6KDM4E
SCHEMBL10684886 0.84 CYP3A4 (0.64) AOC3CYP1A2CYP3A4CYP2D6KDM4E
SCHEMBL9828817 0.83 CYP1A2 (0.62) AOC3CYP1A2CYP3A4CYP2D6KDM4E
SCHEMBL9829415 0.83 CYP1A2 (0.62) AOC3CYP1A2CYP3A4CYP2D6KDM4E
SCHEMBL9829422 0.83 CYP1A2 (0.62) AOC3CYP1A2CYP3A4CYP2D6KDM4E
SCHEMBL25453163 0.82 CYP1A2 (0.70) AOC3CYP1A2CYP3A4CYP2D6KDM4E
Hydrochloric Acid SCHEMBL9828254 0.82 PMP22 (0.63) AOC3CYP1A2CYP3A4CYP2D6KDM4E
Hydrochloric Acid SCHEMBL9829880 0.82 PMP22 (0.63) AOC3CYP1A2CYP3A4CYP2D6KDM4E
Hydrochloric Acid SCHEMBL9828251 0.82 PMP22 (0.63) AOC3CYP1A2CYP3A4CYP2D6KDM4E
SCHEMBL9157545 0.81 CYP3A4 (0.64) AOC3CYP1A2CYP3A4CYP2D6KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5650270-A DETECTABLE SIGNALS FOR LABELS AND ANALYZING NORTHEASTERN UNIVERSITY (US) 1997-07-22 US disclosed
US-5607953-A ANTIISCHEMIC AGENTS EISAI CO., LTD. (JP) 1997-03-04 US disclosed
EP-0344577-B1 Butenoic or propenoic acid derivatives EISAI CO LTD (JP) 1996-10-09 EP disclosed
US-5430059-A Treating heart disease EISAI CO., LTD. (JP) 1995-07-04 US disclosed
EP-0399358-B1 Butenoic acid derivatives EISAI CO LTD (JP) 1995-03-08 EP disclosed
US-5382595-A Antiischemic agents EISAI CO., LTD. (JP) 1995-01-17 US disclosed
EP-0633248-A1 Butenoic acid derivatives Eisai Co., Ltd. (JP) 1995-01-11 EP disclosed
EP-0589491-A1 Butenoic acid derivatives Eisai Co., Ltd. (JP) 1994-03-30 EP disclosed
US-5292770-A Butenoic acid derivatives EISAI CO., LTD. (JP) 1994-03-08 US disclosed
US-5177089-A Antiischemic agent, vasodilator EISAI CO., LTD. (JP) 1993-01-05 US disclosed
US-5166188-A Cardiovascular disorders, antiischemic agents EISAI CO., LTD. (JP) 1992-11-24 US disclosed
US-5047417-A Butenoic or propenoic acid derivatives EISAI CO. LTD. (JP) 1991-09-10 US disclosed
EP-0399358-A2 Butenoic acid derivatives Eisai Co., Ltd. (JP) 1990-11-28 EP disclosed
EP-0344577-A2 Butenoic or propenoic acid derivatives Eisai Co., Ltd. (JP) 1989-12-06 EP disclosed