Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828185 | 0.93 | KDM4E (0.66) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828364 | 0.92 | MAPT (0.76) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828385 | 0.92 | MAPT (0.76) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828278 | 0.91 | MAPT (0.62) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828259 | 0.91 | MAPT (0.62) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828311 | 0.90 | MAPT (0.60) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828130 | 0.89 | MAPT (0.59) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828430 | 0.89 | MAPT (0.59) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828361 | 0.89 | MAPT (0.59) | MAPTLMNAKDM4EALDH1A1PKM | |
| SCHEMBL8828333 | 0.89 | MAPT (0.58) | MAPTLMNAKDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |